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Alertgy has recently been founded by a small team of innovators that have collaborated on challenging technical programs over the years, specifically to address the highly desired ability to measure blood sugar levels with an external wearable sensor device. The team has demonstrated taking technical laboratory concepts to proof of principal demonstrations, and scaling to global commercialization in several industries. We have also undertaken and completed an exhaustive review of the literature from the perspective of biology, analytical chemistry, physics and engineering, and have determined that it is possible to develop a non-intrusive blood sugar alert system, using existing technologies and manufacturing methods. To achieve an accurate measurement of blood sugar in a non-intrusive mode we must realize the complexity of the problem from an analytical perspective.